Week 6 College Football Predictions: Expert Picks Against the Spread

As the excitement of Week 6 of college football approaches, several key matchups are set to command attention, with expert predictions providing insights into which teams may prevail against the spread.

Key Matchups and Predictions

Miami vs. Florida State

This classic rivalry pits the No. 4 Miami Hurricanes (4-0) against the No. 19 Florida State Seminoles (3-1). This matchup marks the first time since 2016 that both teams are ranked. Given Florida State’s recent double-overtime loss to Virginia, they will be eager to bounce back. Miami’s strong overall performance has made them contenders for the national title, relying on their well-rounded team to face a potent Seminoles offense.

BYU vs. West Virginia

• Prediction: BYU favored by 18.5 points
• Freshman quarterback Bear Bachmeier has a remarkable record with 10 total touchdowns and no turnovers.
• The Cougars boast a prolific running game with LJ Martin, averaging 7.3 yards per carry.

Illinois vs. Purdue

• Prediction: Illinois favored by 9.5 points
• Despite a tough previous win, Illinois is expected to perform well against Purdue.

Kentucky vs. Georgia

• Prediction: Kentucky underdogs at +20.5
• Georgia aims to continue their winning streak but recent games against Kentucky have been closer than expected.

Cincinnati vs. Iowa State

• Prediction: Cincinnati favored by 1.5 points
• The Bearcats feature a top 10 offense led by dual-threat quarterback Brendan Sorsby.

Wisconsin vs. Michigan

• Prediction: Wisconsin underdogs at +17.5
• The Badgers possess a tough run defense, providing a chance to challenge the run-heavy Wolverines.

Clemson vs. North Carolina

• Prediction: Clemson favored by 14 points
• After recent heavy losses, Clemson must regain composure against North Carolina.

Penn State vs. UCLA

• Prediction: Penn State favored by 25.5 points
• Penn State faces the only winless power conference team, presenting a strong opportunity for a large margin victory.

Texas vs. Florida

• Prediction: Texas favored by 7 points
• This matchup features two promising young quarterbacks and is expected to be tightly contested.

Vanderbilt vs. Alabama

• Prediction: Vanderbilt underdogs at +10.5
• The Commodores come in strong after recent high-scoring games and a past upset against Alabama.

Oklahoma vs. Kent State

• Prediction: Oklahoma favored by 45.5 points
• With quarterback John Mateer sidelined, the Sooners are seen as vulnerable.

Mississippi State vs. Texas A&M

• Prediction: Mississippi State underdogs at +14
• The Bulldogs have shown resilience and determination this season, making them a team to watch.

Expert Betting Insights

As Week 6 approaches, the spotlight will be on these key matchups and expert predictions reflect the unpredictability of college football. Fans and gamblers alike should keep an eye on these games to see how they unfold against the spread.