Thursday Night Football This Week: Seahawks vs Arizona Cardinals Stats, Schedule, and What Channel to Watch Tonight

The NFC West rivalry between the Seattle Seahawks and Arizona Cardinals takes center stage on Thursday Night Football. Both teams enter Week 4 with 2-1 records, and the outcome could have early implications for the division race. Seattle arrives with one of the league’s most suffocating defenses, while Arizona looks to overcome injuries and protect its home turf at State Farm Stadium.

Seahawks vs Cardinals Odds and Betting Insights

Oddsmakers project a tight matchup, giving Seattle a slight edge on the road.

Latest Betting Lines

Seattle has dominated the series historically, winning eight of the last nine meetings. Arizona, however, benefits from the short-week home advantage often seen on Thursday Night Football.

Thursday Night Football Schedule and Kickoff Details

The matchup is one of the most anticipated games of Week 4.

• Date: Thursday, September 25, 2025

• Kickoff: 8:15 p.m. ET / 5:15 p.m. PT

• Venue: State Farm Stadium, Glendale, Arizona

Seattle has found success in prime-time games under Pete Carroll, while Arizona looks to build momentum with Kyler Murray leading the offense.

What Channel is Thursday Night Football on Tonight

Fans nationwide can catch the game exclusively on Amazon Prime Video. For local viewers, there are additional options:

• Arizona market: Fox 10 (KSAZ)

• Seattle market: Fox 13 (KCPQ)

• Streaming: Prime Video, FuboTV, Sling TV, YouTube TV, Twitch (regional availability may vary)

• Radio: Westwood One nationally, with local calls in English and Spanish including Fuego Radio 106.7 FM in Arizona

This mix ensures fans across markets won’t miss the action.

Seahawks Injury Report and Key Returns

Seattle’s defense looks healthier entering this matchup. Devon Witherspoon and Julian Love are back in the secondary, while linebacker Boye Mafe and guard Anthony Bradford are active. Running back Zach Charbonnet also returns, providing depth behind Kenneth Walker III.

Inactive Seahawks players include:

• Nick Emmanwori

• Josh Jones

• Cody White

• Connor O’Toole

• Jared Ivey

• Mason Richman

• Nick Kallerup

Cardinals Uniform Redesign and Roster Challenges

Arizona unveils a new end zone design at State Farm Stadium, part of the Cardinals uniform redesign that has generated buzz among fans. But roster concerns overshadow the aesthetics. Star running back James Conner is out for the season with a torn ACL, leaving rookie Trey Benson to handle lead duties.

Inactive Cardinals players include:

• Zay Jones (WR)

• Will Johnson (CB)

• Xavier Thomas (LB)

• Will Hernandez (OL)

• Demontrey Jacobs (OL)

• Travis Vokolek (TE)

With a thinner depth chart, Arizona leans heavily on Murray’s connection with rookie wideout Marvin Harrison Jr.

Seahawks vs Cardinals Rivalry History

The Seahawks vs Cardinals rivalry has delivered memorable contests over the years. Seattle currently leads the all-time series 29–22–1, with Russell Wilson once dominating Arizona defenses. Now in the Geno Smith era, Seattle continues its momentum with a defensive identity.

Arizona aims to flip the script at home, fueled by a new wave of offensive talent. This divisional battle remains one of the most competitive rivalries in the NFC West.

Seahawks vs Cardinals Stats Breakdown

Seattle’s defense sets the tone statistically:

• 179 yards allowed per game – best in the NFL

• 3.1 yards per play allowed – lowest in the league

• 0 rushing touchdowns allowed – showing elite run-stopping ability

Arizona counters with:

• Strong run defense and positive turnover margin

• Slower offensive pace, limiting overall possessions

• Kyler Murray’s mobility as a key offensive weapon

These stats show a clash of styles: Seattle’s structured defense against Arizona’s explosive but inconsistent attack.

How to Stream Seahawks Cardinals TNF Anywhere

For fans outside the local broadcast areas, streaming provides flexibility:

• Amazon Prime Video is the primary option nationwide

• FuboTV and Sling TV carry local affiliates in select regions

• YouTube TV offers coverage for both local markets

• Twitch provides additional live access for Prime members

With multiple streaming options, viewers can watch on smart TVs, laptops, or mobile devices without missing a play.