Yankees vs White Sox Prediction: Can New York Dominate Again at Yankee Stadium?

The New York Yankees welcome the Chicago White Sox to Yankee Stadium on Wednesday, September 24, in a matchup that heavily favors the home side. With New York already clinching a playoff spot, the focus shifts to maintaining momentum against a struggling White Sox team.
Yankees vs White Sox Odds
Team | Moneyline | Run Line | Total Runs |
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Yankees | –375 | –1.5 (–164) | O/U 8 |
White Sox | +300 | +1.5 (+138) | O/U 8 |
The Yankees enter as strong favorites, while the White Sox are positioned as major underdogs in this contest.
Probable Pitchers
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Yankees: Max Fried (18–5, 2.92 ERA)
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White Sox: Fraser Ellard (0–2, 4.50 ERA)
Fried has been dominant all season and remains a Cy Young contender, while Ellard brings limited MLB experience into a tough environment.
Yankees White Sox Preview
Offensively, the Yankees lead MLB in runs scored and OPS, showcasing power and consistency. The White Sox, on the other hand, rank near the bottom in both categories and have struggled to generate runs throughout the season.
Recent form also favors New York, who clinched the postseason on José Caballero’s walk-off hit against Chicago in their last meeting.
Yankees Betting Pick
Analysts give the Yankees a win probability of more than 70%, with projected scorelines around 5–2 or 5–3. Betting experts recommend:
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Backing Yankees –1.5 on the run line
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Taking the under on 8 total runs
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Considering props like White Sox scoring zero runs in the first three innings
The yankees vs white sox prediction points clearly toward a comfortable Yankees victory, backed by elite pitching, superior offense, and strong home-field advantage.