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The Miami Dolphins visit the Buffalo Bills in a pivotal AFC East clash on Thursday Night Football to open Week 3 of the 2025 NFL season. The game promises fireworks, but both franchises enter in very different positions.

The Bills are off to a strong 2-0 start and already look like serious Super Bowl contenders. Meanwhile, the Dolphins are winless (0-2), struggling on both sides of the ball, and facing mounting criticism with head coach Mike McDaniel already mentioned as being on the hot seat.

What time does Bills vs. Dolphins start?

• Date: Thursday, Sept. 18, 2025

• Kickoff Time: 8:15 p.m. ET

What channel is Bills vs. Dolphins on today?

• Buffalo market: WKBW

• Miami market: WFOR

• National broadcast: Amazon Prime Video (exclusive stream for Thursday Night Football)

Fans outside of local markets must stream the matchup with an Amazon Prime Video subscription, the official home of "TNF."

Josh Allen vs. Dolphins: MVP Quarterback in the Spotlight

Reigning NFL MVP Josh Allen has owned Miami in recent years. In 15 career meetings, he has accounted for 45 total touchdowns against the Dolphins – the most he has against any opponent.

Allen’s hot start to the season has fueled Buffalo’s unbeaten record, including a comeback win over the Ravens in Week 1 and a dominant performance against the Jets in Week 2.

Tyreek Hill and Tua Tagovailoa under pressure

For the Dolphins, Tua Tagovailoa and Tyreek Hill must find their rhythm if Miami hopes to spark the explosive offense that defined McDaniel’s first two seasons. But the offensive line has been shaky, and the defense has been a liability, giving up 33 points in back-to-back weeks.

Bills vs. Dolphins Prediction

Buffalo enters riding several streaks:

• Five straight AFC East titles

• 24 consecutive games without losing the turnover battle

• Eight straight home wins over Miami

Those trends are expected to continue. With Miami’s defense struggling and Buffalo’s offense firing on all cylinders, the Bills are heavy favorites.

Prediction: Bills 41, Dolphins 13

Bills vs. Dolphins Odds and Betting Line

• Spread: Bills -10.5

• Moneyline: Bills -450, Dolphins +350

• Over/Under: 48.5

Key Injury Report: Is Jaylen Waddle Playing Tonight?

Wide receiver Jaylen Waddle was questionable with a shoulder injury suffered in Week 1 but has been cleared to play. He is expected to take on a full workload against Buffalo.

AFC East Standings heading into Week 3

• Buffalo Bills (2-0)

• New England Patriots (1-1)

• New York Jets (0-2)

• Miami Dolphins (0-2)

How to watch Bills vs. Dolphins live stream

The game is available exclusively on Amazon Prime Video for national viewers. Local markets can watch on WKBW (Buffalo) and WFOR (Miami).