Thursday Night Football This Week: Dolphins vs Bills Clash, Predictions, Key Stats, and How to Watch Live

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thursday night football this week

The NFL spotlight is shining brightly on Thursday Night Football this week as the Miami Dolphins travel to Orchard Park to face the Buffalo Bills in a high-stakes AFC East showdown. With the Bills riding momentum from back-to-back wins and the Dolphins desperate to snap a losing streak, fans are set for one of the most exciting primetime games of the season.

Dolphins vs Bills: Game Details and Broadcast Information

The Bills vs Dolphins game will kick off on Thursday, September 18, 2025, at 8:15 p.m. ET from Highmark Stadium in Buffalo. Coverage begins at 7:00 p.m. ET, exclusively on Prime Video. Local fans in Buffalo and Miami will also have the option to watch via over-the-air broadcasts in their respective markets. NFL+ provides streaming access for subscribers on mobile and tablet devices.

Amazon’s Prime Video has also introduced new AI-powered features for Thursday Night Football this week, including Pocket Health, which analyzes quarterback pressure, and enhanced end-of-game predictive models, giving fans deeper insights throughout the matchup.

Bills vs Dolphins Predictions and Betting Odds

Sportsbooks have labeled the Bills as strong favorites heading into this AFC East clash. Buffalo is seeking its seventh straight win over Miami, and with home-field advantage on Thursday night, the odds remain heavily tilted in their favor.

For Bills vs Dolphins predictions, experts highlight Buffalo’s balanced offense led by quarterback Josh Allen and running back James Cook stats, who has emerged as a dual-threat playmaker in the run and pass game. Miami, meanwhile, will lean on its explosive playmaker Tyreek Hill stats to break open plays against Buffalo’s defense.

Key Injuries Impacting Bills Dolphins Showdown

Both teams enter this Dolphins vs Bills contest with significant injury concerns.

The Dolphins have ruled out tight end Darren Waller (hip), cornerback Storm Duck (ankle), and safety Ifeatu Melifonwu (calf). Wide receiver Jaylen Waddle is questionable, adding uncertainty to Miami’s offensive firepower.
The Bills will be without star linebacker Matt Milano (pectoral) and defensive tackle Ed Oliver (ankle), key figures in their defensive front. Several others, including Shaq Thompson and Taron Johnson, are listed as questionable.

These injuries could play a huge role in shaping the outcome of Bills Dolphins this week.

Josh Allen Stats and James Cook Stats Leading Buffalo’s Charge

Quarterback Josh Allen stats have been impressive to start the season, showcasing his trademark arm strength and mobility. His ability to extend plays under pressure makes him the most dangerous player on the field in primetime.

Running back James Cook stats also stand out, with his versatility in rushing and catching passes out of the backfield. Cook’s consistency has given Buffalo a more balanced attack, keeping defenses honest and opening lanes for Allen’s passing game.

Tyreek Hill Stats a Game-Changer for Dolphins vs Bills

If Miami hopes to pull off an upset, they will rely heavily on Tyreek Hill stats. Known for his speed and ability to stretch defenses, Hill remains one of the league’s most explosive wide receivers. His chemistry with the Dolphins’ passing attack will be vital in breaking through Buffalo’s secondary, especially with Jaylen Waddle’s status uncertain.

Bills Game Tonight: Rivalry, Stakes, and Momentum

The Bills game tonight is more than just a divisional matchup—it’s a statement game. Buffalo has dominated this rivalry in recent years, but Miami is desperate to avoid a 0–3 start to the season. With national attention on Thursday Night Football this week, the intensity will be sky-high.

For fans and bettors alike, the Dolphins vs Bills prediction hinges on whether Miami’s offense can overcome Buffalo’s defensive pressure and if Josh Allen continues his hot streak under the primetime lights.