NFL Week 5: Buccaneers vs. Seahawks – Predictions, Picks, and Best Bet

As the NFL season progresses, Week 5 presents an exciting matchup between the Tampa Bay Buccaneers and the Seattle Seahawks. Scheduled for October 5, 2025, this game will take place at Lumen Field in Seattle, Washington, with kickoff set for 4:05 p.m. ET and CBS providing live coverage.
Bucs and Seahawks: A Battle of 3-1 Teams
Both teams enter this game with a record of 3-1. The Seahawks, riding a three-game win streak, have shown resilience after losing their season opener. Meanwhile, the Buccaneers are looking to recover after suffering their first defeat of the season against the Philadelphia Eagles.
Key Matchup Insights
- The Seahawks have stacked victories against the Pittsburgh Steelers (3-1), New Orleans Saints (0-4), and Arizona Cardinals (2-2).
- The Buccaneers have claimed wins against the New York Jets, Atlanta Falcons, and Houston Texans, but they have yet to defeat a team with a winning record.
- Seattle’s quarterback, Sam Darnold, ranks in the top 10 in several key statistics, including completion percentage and QB rating.
Injury Concerns
The Buccaneers face notable injury issues, particularly with Baker Mayfield possibly missing key players like Mike Evans and Bucky Irving. Historically, the Buccaneers have struggled without Evans, posting an 0-4 record since 2023 in such games.
Predictions and Betting Odds
The Seahawks are favored in this matchup, with the spread set at Seattle -3.5. Betting trends suggest that the Seahawks have consistently covered the spread, winning their last three games.
Betting Favorites
- Best Bet: Seattle Seahawks -3.5 (-110)
- Moneyline: Seahawks -194, Buccaneers +162
- Total Points Prediction: Under 44.5, with the Under hitting in two of the Buccaneers’ games this season.
Same-Game Parlay Suggestions
- Seahawks -3.5
- Sean Tucker Under 27.5 rushing yards
- Kenneth Walker to score anytime
- Cade Otton to score anytime
- Cooper Kupp Over 3.5 receptions
Game Details
This highly anticipated game will take place under favorable weather conditions, with sunny skies and temperatures around 62 degrees. Fans and analysts alike are keenly watching how this matchup unfolds as both teams aim to solidify their playoff aspirations.